All News - ALZFORUM
Dec 7, 2024 · TYPE OF NEWS. Research News (4510) Conference Coverage (1414) Community News (278) Interviews (33) Book Reviews (7) DISEASE. Alzheimer's Disease (3349) Amyotrophic Lateral Sclerosis (541) Parkinson's Disease (477) Frontotemporal Dementia (435) Triplet Repeat Diseases (153) Dementia with Lewy Bodies (116) Progressive Supranuclear Palsy (95 ...
Some Alzheimer’s Blood Tests Are Racing Toward IVD Certification
Nov 21, 2024 · News Citations. FDA Will Regulate Diagnostic Tests. Yes, Those for Alzheimer’s, Too. 10 May 2024; By Setting Standards, Experts Aim to Tame a Wild West of AD Blood Tests 21 Aug 2024; Results from IDEAS Study Published 3 Apr 2019; AMYPAD Confirms: Amyloid PET Improves Diagnosis 8 Sep 2022; AD Blood Tests Are Here.
In Alzheimer’s Due to Down’s, Spatial Omics Spots Signs of Trouble
Dec 7, 2024 · In 5xFAD mice, a similar analysis revealed substantial overlap in plaque-associated genes between mouse and human samples. Swarup said the findings bolster previous studies on plaque-induced genes, aka “PiGs” (Jul 2020 news; Feb 2023 news). The agreement across species suggests a common, amyloid-related signature at the heart of different ...
ALZFORUM | NETWORKING FOR A CURE
5 days ago · In Alzheimer’s Due to Down’s, Spatial Omics Spots Signs of Trouble. Add To My AlzForum; 1 comment; 07 Dec 2024. In plaque- and tangle-laden layers of the Down’s syndrome neocortex, neuroinflammation raged, and glia sent death signals to neurons. Do CSF and Plasma NfL Diverge After Alzheimer’s Disease Onset? Add To My AlzForum; 06 Dec 2024
Polygenic Scores Point to Microglia, Astrocytes in Alzheimer's ...
Dec 15, 2023 · Curiously, only the astrocytic PRS was tied to poor scores on the preclinical Alzheimer’s cognitive composite (PACC), a test battery that picks up early inklings of cognitive impairment. This held regardless of a person's Aβ or tau-PET measures, suggesting astrocytes might directly influence early changes in cognition.
CSF Proteins Spot Alzheimer’s Mutation Carriers Decades Before …
Sep 27, 2024 · Three of the proteins—SMOC1, GFAP, and NPTX2—are included in Alamar’s CNS Nulisa platform, a new technique that use nucleic acid tags to amplify antibody signals and detect vanishingly minute amounts of protein (Aug 2024 conference news). Even with just these three proteins, Nulisa measurements teased out mutation carriers, and their ...
Finally, Therapeutic Antibodies Start to Reduce Tangles
Nov 14, 2024 · For his part, Boxer has been planning for some years to launch the Alzheimer’s Clinical Trial Consortium tau platform trial, aka ATP, to test two tau therapies alone or in combination with amyloid drugs (Aisen et al., 2021; Nov 2021 conference news). He hopes ATP will start up in 2025.
Astrocyte transcriptomic changes along the spatiotemporal …
Dec 6, 2024 · News: Astrocytes Mount Complex Responses to AD. They Change Over Time They Change Over Time This was an ambitious study using single-nucleus RNA-Seq to characterize astrocyte heterogeneity across five brain regions in 32 donors who spanned the spectrum of Alzheimer’s disease neuropathology.
All News | ALZFORUM
Nov 27, 2024 · ALL NEWS. 1 RESULT . Sort By: Most Recent; Most Commented ... Alzheimer’s Association diagnostic ...
Fully Loaded: Secondary Prevention Studies of Lecanemab, …
Previously, Eisai had requested approval for IV maintenance dosing, as well (May 2024 news). And days after CTAD, news broke that European regulators reversed their July 2024 rejection of lecanemab, and are now recommending approval (EMA release). Preclinical Populations. On the plaque accumulation curve (red), the A3 cohort (orange circle) is ...
- Some results have been removed