The senescence-associated secretory phenotype and its ... - Nature
Apr 23, 2024 · We describe the various biological properties of the SASP, its beneficial and detrimental effects in different physiological and pathological settings, and its impact on overall health span.
Senescence-associated secretory phenotype - Wikipedia
Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators, growth factors, and proteases. [1] [2] SASP may also consist of exosomes and ectosomes containing enzymes, microRNA, DNA fragments, chemokines, and other bioactive ...
Researchers explore whether senescence-associated ... - Mayo Clinic
Jan 7, 2021 · A Mayo Clinic study suggests that senescence-associated secretory phenotype (SASP) proteins could help identify people at risk of functional decline and those who may benefit from preventive intervention.
Overcoming the senescence‐associated secretory phenotype (SASP…
In this review, we will focus on recent evidence regarding therapy‐induced senescence (TIS) from anticancer agents, including chemotherapy, radiation, immunotherapy, and targeted therapies, and how each therapy can trigger the SASP, which in turn influences treatment efficacy.
The role of the dynamic epigenetic landscape in senescence ...
Oct 24, 2024 · This review outlines the current understanding of how senescent cells undergo epigenetic changes and how these alterations govern SASP expression.
Apoptotic stress causes mtDNA release during senescence and drives the SASP
Oct 11, 2023 · We find that inhibition of MOMP in vivo decreases inflammatory markers and improves healthspan in aged mice. Our results reveal that apoptosis and senescence are regulated by similar...
The senescence-associated secretory phenotype and its …
May 1, 2019 · Senescence cells of any origin reprogram their genome and metabolism to become secretory cells. The Senescence-Associated Secretory Phenotype (SASP) includes cytokines, chemokines, growth factors, proteases and lipids. The SASP mediates tumor suppression and wound healing but also chronic inflammation and age-related diseases.
The Senescence-Associated Secretory Phenotype: The Dark Side of …
SASP proteases can have three major effects: (a) shedding of membrane-associated proteins, resulting in soluble versions of membrane-bound receptors, (b) cleavage/degradation of signaling molecules, and/or (c) degradation or processing of the ECM. These activities provide potent mechanisms by which senescent cells can modify the tissue ...
Senescence and the SASP: many therapeutic avenues
Dec 1, 2020 · Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP).
A proteomic atlas of senescence-associated secretomes for aging ...
Jan 16, 2020 · The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.