Geranylgeranyl pyrophosphate - Wikipedia
Geranylgeranyl pyrophosphate is an intermediate in the biosynthesis of diterpenes and di terpenoids. [1] It is also the precursor to carotenoids, gibberellins, tocopherols, and chlorophylls. It is also a precursor to geranylgeranylated proteins, which is its primary use in human cells. [2]
Genome-wide identification of the geranylgeranyl pyrophosphate …
Apr 5, 2023 · Geranylgeranyl pyrophosphate synthase (GGPS) is a structural enzyme in the terpene biosynthesis pathway and a member of the isopentenyl pyrophosphate synthase gene family.
Geranylgeranyl diphosphate synthase: Role in human health, …
Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthesis pathway, is responsible for the production of geranylgeranyl pyrophosphate (GGPP) used for protein geranylgeranylation.
Isolation, expression, and functional analysis of the geranylgeranyl …
Sep 1, 2021 · Geranylgeranyl pyrophosphate synthase (GGPPS) is a key synthase in the 2C-methyl-D-erythritol-4-phosphate (MEP) pathway of terpenoid synthesis, catalyzing the synthesis of diterpenoids. Liriodendron tulipifera is a nectar plant in North America.
Genome-wide identification of the geranylgeranyl pyrophosphate …
Apr 5, 2023 · Geranylgeranyl pyrophosphate synthase (GGPS) is a structural enzyme of the terpene biosynthesis pathway that is involved in regulating plant photosynthesis, growth and development, but this gene family has not been systematically studied in cotton.
Intracellular lipid surveillance by small G protein ... - Nature
May 18, 2022 · To determine whether geranylgeranyl pyrophosphate is a critical determinant in lipid sensing, we investigated whether its levels become depleted at the time of pathway activation.
Geranylgeranyl Pyrophosphate - an overview | ScienceDirect …
Geranylgeranyl pyrophosphate is a 20-carbon long-chain compound formed through the condensation of simple isoprene units, which serves as a metabolic hub for the synthesis of various pigments and secondary metabolites such as chlorophyll, carotenoids, and gibberellins.
Geranylgeranyl Pyrophosphate - an overview - ScienceDirect
Geranylgeranyl pyrophosphate (GGPP), an endogenous mevalonate pathway intermediate, has been shown to be a strong inhibitor of ABCA1 and ABCG1 mRNA synthesis in THP-1 cells and in CaCo2 intestinal cells [125]. The major inhibitory mechanism of GGPP is mediated via the DR4 element in the ABCA1 promoter.
Cholesterol metabolism drives regulatory B cell IL-10 through ... - Nature
Jul 8, 2020 · Synthesis of the metabolic intermediate geranylgeranyl pyrophosphate (GGPP) is required to specifically drive IL-10 production, and to attenuate Th1 responses.
Engineering of geranylgeranyl pyrophosphate synthase levels …
Abstract. The basidiomycetous yeast, Xanthophyllomyces dendrorhous, is one of the very few organisms which can be used for biological production of the carotenoid astaxanthin. crtE cDNA has been cloned from this fungus for engineering of the terpenoid pathway.