Chromatography Online
Researchers employed a gas chromatography-mass spectrometry (GC–MS)-based metabolomic approach combined with sophisticated statistical methods to identify metabolic biomarkers in coronary heart disease (CHD), hypertension-comorbid CHD, depression-comorbid CHD, and type 2 diabetes mellitus (T2DM)-comorbid CHD to provide an objective diagnostic method and help identify metabolomic signatures ...
Ultraviolet Detectors: Perspectives, Principles, and Practices
Oct 1, 2019 · Requirements and Desirable Characteristics of UV Detectors. Table II summarizes the requirements and desirable characteristics of a modern UV detector (VWD or DAD), followed by a discussion of historical perspectives, optical designs, operating principles, and common operation and maintenance procedures.
The Flame Ionization Detector - Chromatography Online
Dec 1, 2005 · John V. Hinshaw Although these ionization detectors share several features, their implementations differ significantly. Detector performance characteristics (sensitivity, minimum detectable quantity, linearity, and selectivity) are affected strongly by the type of ionization mechanism, the internal electrode arrangement, and the electronics.
Certificate of Analysis (CoA) and Calculations for Small-Molecule …
Jun 10, 2024 · Case Studies from an Early-Phase Small-Molecule Development Project: Background Information. A case study from my experience as a chemistry, manufacturing, and controls (CMC) analytical team lead supporting an early-phase small-molecule oncology drug development project was used to illustrate how CoAs expedite quality documentation of testing methods and results.
LCGC International - Chromatography Online
Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.
About LCGC International - Chromatography Online
Jan 1, 2019 · Founded in 1983, LCGC International is the leading provider of digital and print content to the separation science market, enhancing the productivity, efficiency, and the overall value of separation techniques globally. With our commitment to editorial excellence, we have pioneered innovation across a broad portfolio of digital and print platforms.
Chromatography Fundamentals, Part VIII: The Meaning and …
Nov 1, 2019 · The effectiveness of a separation can be quantified by measuring the resolution. This article explains the factors influencing resolution and the equation for predicting the required number of theoretical plates to obtain a given esolution.
LCGC Europe - Chromatography Online
Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.
Current Good Manufacturing Practice (cGMP): An Overview for the ...
Nov 1, 2023 · The complex and multifaceted GMP regulations and compliance requirements and practices can be found in the regulatory source documents (1–9) and public guidance (10,11), textbooks (12–15), book chapters (16), journal review articles (17–19), and training resources from university programs (for example, regulatory affairs or pharmaceutical sciences) (20) and professional training courses ...
LCGC North America - Chromatography Online
Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.