New Genetic Link to Autism Identified on X Chromosome - Neuroscience News
5 days ago · Credit: Neuroscience News In the study published today, researchers from The Hospital for Sick Children (SickKids) in Canada and the Istituto Giannina Gaslini in Italy clinically tested 10 individuals with ASD from 8 different families and found that variants in the DDX53 gene were maternally inherited and present in these individuals.. Notably, the majority were male, highlighting the gene ...
Genetic discovery reveals 'direct link' to autism — what to know
5 days ago · A small study of 10 kids — mostly boys — with autism showed that they had variants in the DDX53 gene, which is primarily expressed in the testis and brain.
Genetic discovery links new gene to autism spectrum disorder
6 days ago · The variants were found in genes linked to autism, including PTCHD1-AS (near to DDX53), DMD, HDAC8, PCDH11X, and PCDH19 beside novel ASD-linked candidates ASB11 and ASB9. Additionally, the FGF13 gene was highlighted as being related to ASD, with sex-specific differences, adding more evidence to the role of sex chromosomes in the condition.
Genetic discovery links new gene to autism spectrum disorder
5 days ago · Genetic variants in DDX53 contribute to autism spectrum disorder associated with the Xp22.11 locus. The American Journal of Human Genetics , 2024; DOI: 10.1016/j.ajhg.2024.11.003
Study uncovers a previously unknown genetic link to autism …
5 days ago · The variants were found in genes linked to autism, including PTCHD1-AS (near to DDX53), DMD, HDAC8, PCDH11X, and PCDH19 beside novel ASD-linked candidates ASB11 and ASB9.
Newly identified gene sheds light on boys’ susceptibility to autism
2 days ago · In the tangled forest that is the genetics of autism, scientists have a new guidepost. For the first time, a gene called DDX53 has been associated with the complex developmental disorder.
Genetic variants in DDX53 contribute to autism spectrum disorder ...
6 days ago · Through clinical testing, here, we identified 8 males and 2 females with ASD from 8 unrelated families carrying rare, predicted damaging or loss-of-function variants in DDX53.
Autism Spectrum Disorder Studies Dig Into X Chromosome …
6 days ago · NEW YORK – A pair of new studies by investigators at Toronto's Hospital for Sick Children (SickKids) has uncovered autism spectrum disorder (ASD)-associated variants on the X chromosome, including in a helicase-coding gene called DDX53.
DDX53 News Research Articles - Neuroscience News
6 days ago · Researchers identified variants in the DDX53 gene, located on the X chromosome, as contributors to autism spectrum disorder (ASD). These genetic variants, found predominantly in males, provide critical insights into the biological mechanisms behind …
Disruption of DDX53 coding sequence has limited impact on iPSC …
Jan 12, 2023 · Males who carry chromosome microdeletions of PTCHD1 antisense long non-coding RNA (PTCHD1-AS)/DEAD-box helicase 53 (DDX53) have ASD, or a sub-clinical form called Broader Autism Phenotype.
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