Jul 1, 2017 · A. p16 immunohistochemistry is not recommended as a routine adjunct assessment when the biopsy interpretation is negative, CIN I or CIN III. Strong and diffuse block staining for p16 …

p16 (by immunohistochemistry) for anogenital carcinomas and premalignant lesions Negative (cytoplasmic only staining, patchy nonblock type staining or diffuse blush / weak intensity staining) …

Feb 12, 2025 · Squamous dysplasia is noninvasive neoplastic proliferation of the anal squamous epithelium with cytologic and architectural abnormalities; it is associated with human papillomavirus …

Sep 17, 2025 · p16: diffuse and strong nuclear and cytoplasmic reactivity (block type staining); improper use / interpretation may lead to overdiagnosis of HSIL Surgical excision is the treatment of choice, …

Oct 30, 2020 · The p16 immunohistochemistry, a diagnostic tool for HPV related neoplastic condition including HSIL, can solve the problem since squamous metaplasia is negative for this particular maker.

Nov 25, 2025 · Positive stains p16: strong and diffuse block-like positivity in HPV related adenocarcinoma in situ types, patchy or negative staining in gastric type (rarely overexpressed) …

Nov 20, 2019 · Cytomorphologic overlap Also p16 + and high risk HPV+ Adenoid cystic carcinoma, solid type Basaloid tumor cells with high N/C ratio and angulated nuclei CD117 (c-kit)+ p16 -, high risk …

Immunostains, routine stains and CD markers at PathologyOutlines.com

Sep 3, 2020 · Positive for both p16 (diffuse, block-like) and p53 (aberrant patterns, see Negative stains) Mimics: EEC with papillary architecture (villoglandular, small nonvillous papillae, micropapillae): Less …

Oct 18, 2022 · Diffuse p16 expression may suggest cervical origin of a squamous carcinoma Reactive / reparative Atypical polypoid adenomyoma: Polypoid lesion with prominent myofibroblastic stroma …