Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene.

Oct 1, 2022 · Interleukin 6 (IL-6) is a 26-kDa secreted protein, mature IL-6 consists of 184 amino acids and two N-glycosylation sites as well as four cysteine residues. IL-6 is a multifunctional …

Sep 28, 2023 · Interleukin 6 (IL-6) is a pleiotropic cytokine executing a diverse number of functions, ranging from its effects on acute phase reactant pathways, B and T lymphocytes, …

Mar 29, 2021 · Besides being an immune protein, IL-6 is also a pyrogen and is responsible for fever in autoimmune, infectious, or non-infectious diseases. IL-6 is produced in the body, …

Jun 26, 2025 · Interleukin-6, or IL-6, is a protein that functions as a signaling molecule, or cytokine, that acts as a messenger between cells to coordinate various biological processes.

Interleukin-6 (IL-6) is a multifaceted cytokine that serves as a critical mediator in immune regulation, inflammation and tissue regeneration. Its activity is mediated through several …

Interleukin-6 (IL-6) is a cytokine which plays a prominent role in the coordinated systemic host defense response to injury. IL-6 regulates immune and inflammatory responses, hepatic acute …

Apr 16, 2021 · IL-6 has since emerged as a master regulator of inflammation and one of the few truly pleiomorphic cytokines, alongside IL-1 and tumour necrosis factor (TNF). The three …

IL-6 is a broad acting cytokine and an important therapeutic target for the treatment of diseases such as inflammatory rheumatic diseases and some cancers.

Here, we review the current state of IL-6-targeting approaches in the clinic and discuss how to apply the growing understanding of the immunobiology of IL-6 to clinical decisions.