CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.

This Review describes the journey taken by the MHC-class-I-like CD1 molecules, detailing their assembly, intracellular trafficking and loading with lipid antigens.

CD1 molecules are glycosylated heterodimers composed of a heavy chain polypeptide non-covalently associated with β2-microglobulin (β2m). Group I and II CD1 proteins are mainly …

This review summarizes the major features of CD1 genes and proteins, the patterns of intracellular trafficking of CD1 molecules, and how they sample different intracellular …

Here, we solved lipidomes for the four human CD1 antigen-presenting molecules, providing a map of self-lipid display. Answering a basic question, the detection of >2,000 CD1-lipid complexes …

CD1 is structurally and functionally similar to MHC class I and II molecules; however, CD1 presents lipids rather than polypeptides on antigen presenting cells. CD1 has also evolved a …

May 13, 2021 · To sample a diverse antigen pool, CD1 proteins are repeatedly internalized and recycled; this may be assisted by lipid transfer proteins such as saposins (J Biol Chem …

Jun 13, 2025 · CD1 molecules are a family of glycoproteins that play a crucial role in the immune system, particularly in the presentation of lipid antigens to T cells. In this section, we will …

Here, we explain CD1-lipid-TCR interactions, highlight two recent examples of antigen recognition that diverge from accepted models, and summarize recent studies of disease-focused work in …

CD1 refers to a family of glycoproteins that have a structure similar to classical MHC class I molecules and are involved in presenting lipid and glycolipid antigens to T-cells for recognition.