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S35 Randomised control trial quantifying the efficacy of low dose morphine in a responder group of patients with refractory chronic cough

Introduction and objectives The pathophysiology of chronic cough remains poorly understood and treatment options are limited. Morphine sulphate can improve quality of life in refractory chronic cough, ...
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Quantification of dyspnoea using descriptors: development and initial testing of the Dyspnoea-12

Rationale: Dyspnoea is a debilitating and distressing symptom that is reflected in different verbal descriptors. Evidence suggests that dyspnoea, like pain perception, consists of sensory quality and ...
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The five-repetition sit-to-stand test as a functional outcome measure in COPD

1 NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College, Harefield, UK 2 Harefield Pulmonary Rehabilitation Unit, Royal Brompton & Harefield ...
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The Clinical COPD Questionnaire: response to pulmonary rehabilitation and minimal clinically important difference

Background The Clinical COPD Questionnaire (CCQ) is a simple 10-item, health-related quality of life questionnaire (HRQoL) with good psychometric properties. However, little data exists regarding the ...
Thorax

Maternal BMI and smoking partly explain the association between maternal socio-economic position and offspring asthma

Background Numerous studies have found associations between parental socio-economic position (SEP) and offspring asthma.
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Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection

1 Department of Thoracic and HIV Medicine, Royal Free Hospital, London, UK 2 Department of Infectious Diseases, Royal Free Hospital, London, UK 3 Department of Primary Care and Population Sciences, ...
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COPD exacerbations · 1: Epidemiology

The epidemiology of exacerbations of chronic obstructive pulmonary disease (COPD) is reviewed with particular reference to the definition, frequency, time course, natural history and seasonality, and ...
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Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort

The longer-term consequences of SARS-CoV-2 infection are uncertain. Consecutive patients hospitalised with COVID-19 were prospectively recruited to this observational study (n=163). At 8–12 weeks ...
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Cough · 3: Chronic cough and gastro-oesophageal reflux

Dipartimento di Area Critica Medico Chirurgica, Sezione di Medicina Respiratoria, Università di Firenze, Viale G B Morgani, 85 50134 Firenze, Italy Correspondence to: Dr G A Fontana Dipartimento di ...
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Understanding lung disease following extremely preterm birth

Individuals born extremely preterm (EP-born) must complete lung development outside the uterus, affecting the maturation and growth of airways and alveoli. They often show signs of both obstructive ...
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S90 FRONTIER-3: a randomized, phase 2a study to evaluate the efficacy and safety of tozorakimab (an anti-interleukin-33 monoclonal antibody) in early-onset asthma

2 Research and Early Development, Respiratory and Immunology, BioPharmaceuticals RandD, AstraZeneca, Cambridge, UK 3 Respiratory and Immunology, Biometrics and Statistical Innovation, Late Respiratory ...
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Pneumonia in low and middle income countries: progress and challenges

1 Department of Paediatrics and Child Health, Red Cross War Memorial Childrens Hospital, University of Cape Town, Cape Town, South Africa 2 National Institute for Communicable Diseases, Division of ...