Cancer Research4d
ADC for Lymphoma Elicits Near-Perfect Response Rate
In a phase II trial, the ROR1-targeting antibody–drug conjugate zilovertamab vedotin led to a complete response in nearly 100% of patients with diffuse large B-cell lymphoma.
Cancer Research7d
The Neuron–Tumor Connectome Supports Glioblastoma Progression
Major Finding: Tumor-connected neurons promote glioblastoma growth, invasion, and resistance to radiotherapy. Concept: Rabies virus–based retrograde tracing of neurons reveals their integration with ...
Cancer Research7d
Subcutaneous Nivolumab Earns FDA Nod
Bristol Myers Squibb announced that the FDA approved nivolumab and hyaluronidase (Opdivo Qvantig) for subcutaneous injection across all currently approved solid tumor indications for intravenous (IV) ...
Cancer Research8d
Challenges to innovation arising from current companion diagnostics regulations and suggestions for improvements
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
Cancer Research8d
Pediatric Cancer Research Funding Rescued by Senate
After the U.S. Congress pulled funding for a few pediatric cancer programs from the bill passed last week to fund the government through March 14, the Senate voted unanimously to restore a $12.6 ...
Cancer Research8d
Modified CARs Self-Condense to Form Optimal Immunological Synapses
Major Finding: Incorporating a modified CD3ε intracellular domain into a chimeric antigen receptor (E-CAR) improves signaling. Concept: E-CARs phase separate and form mature synapses that support ...
Cancer Research14d
Encorafenib Granted Accelerated Approval for Colon Cancer
The FDA granted accelerated approval to encorafenib (Braftovi; Array BioPharma/Pfizer), a BRAF inhibitor, in combination with the anti-EGFR mAb cetuximab (Erbitux; Eli Lilly) and the chemotherapy ...
Cancer Research15d
Comparison of Shared Class I HLA-bound Non-canonical Neoepitopes between Normal and Neoplastic Tissues of Pancreatic Adenocarcinoma
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
Cancer Research15d
Novel Degrader Shows Anti–Lymphoma and Myeloma Activity
The cereblon E3 ligase modulator cemsidomide showed activity against multiple myeloma and two types of non–Hodgkin lymphoma in a phase I study.
Cancer Research15d
EZH2 Inhibition Enhances T-cell Immunotherapy in B Cell Lymphoma
Major Finding: Pharmacologic inhibition of EZH2 sensitizes preclinical models of B cell lymphoma to T-cell immunotherapy. Concept: EZH2 inhibition enhances T-cell recruitment, T-cell–B-cell ...
Cancer Research15d
Stratified Medicine Paediatrics: Cell free DNA and serial tumour sequencing identifies subtype specific cancer evolution and epigenetic states
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
Cancer Research15d
DOT1L mediates stem cell maintenance and represents a therapeutic vulnerability in cancer
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States ...