The San Francisco 49ers head into Thursday Night Football against the Los Angeles Rams, with a 3-1 record, matching their division rivals. It’s a big early-season matchup, and the 49ers aren’t hiding anything,

The Rams earn the Thursday Night Football stage with a fierce rival in town. Here are bold predictions from Puka Nacua to Nate Landman.

Brock Purdy will miss the 49ers' "Thursday Night Football" game against the Rams after his toe injury flared up, and Mac Jones will make his third start.

Quarterback Brock Purdy will miss his third game of the season because of an injury to his toe. The Niners (3-1) also ruled out starting receivers Ricky Pearsall and Jauan Jennings for the division showdown, with Pearsall out because of a knee injury and Jennings with injuries to his ankle and ribs.

San Francisco 49ers quarterback Brock Purdy (13) and offensive tackle Trent Williams (71) walk off the field after an NFL football game against the Jacksonville Jaguars in Santa Clara, Calif., Sunday, Sept. 28, 2025. Credit: AP/Godofredo A. Vásquez

WOODLAND HILLS, Ca. The Los Angeles Rams have been working around the clock to prepare for their Thursday Night matchup against their arch-rivals, the San Franc

For the first time since October 2022, the 49ers are underdogs against the Los Angeles Rams. The line initially opened with Sean McVay’s squad as 3.5-point favorites. Then, the injury news surfaced for the 49ers,