But, there was one glaring issue in the team’s first game without Nick Bosa: pressure. The 49ers could not generate much ...

The Niners laundry list of injuries finally caught up with them this past weekend as Trevor Lawrence and the Jaguars handed Kyle Shanahan’s squad their first loss. Jacksonville jumped out to a 17-6 ...

Even without Brock Purdy, the San Francisco 49ers were able to get it done. Quarterback Mac Jones led the way as the 49ers ...

The San Francisco 49ers will look to start their season 4-0 for the second time under head coach Kyle Shanahan.

Before the San Francisco 49ers take on the Jacksonville Jaguars, we asked the Chronicle's NFL coverage team for predictions ...

The San Francisco 49ers struggled in their home opener, but they left Week 3 with a win vs. the Arizona Cardinals. Here are ...

NFL Week 4 odds, picks, predictions, TV channel, streaming information for Sunday football game between Jacksonville Jaguars and San Francisco 49ers.

The 49ers found brief momentum with 3 1/2 minutes to play, after Jaguars kicker Cam Little missed a 47-yard field goal.

Trevor Lawrence, Travis Hunter and the Jacksonville Jaguars go west to face the San Francisco 49ers in Week 4 NFL football. See updates and analysis.

One San Francisco 49ers insider believes they should target one former NFL sack leader to replace the injured Nick Bosa.

Kyle Juszczyk of the San Francisco 49ers celebrates after a touchdown against the Arizona Cardinals with teammate Ricky ...

The NFL is making a change to its Week 6 schedule. Here's what to know about the switch, including new kickoff times: ...