The Jacksonville Jaguars have the chance to notch a statement win with a road upset against the San Francisco in Week 4. Can they pull it off?

Jacksonville defensive lineman Travon Walker left the Jaguars’ game against the San Francisco 49ers with a wrist injury.

The San Francisco 49ers will look to start their season 4-0 for the second time under head coach Kyle Shanahan. Standing in their way Sunday at Levi's Stadium will be the Jacksonville ...

San Francisco 49ers middle linebacker Fred Warner nearly intercepts Jacksonville Jaguars quarterback Trevor Lawrence off a deflection from tight end Brenton Strange.

The San Francisco 49ers cannot seem to shake the injury bug. Ricky Pearsall is suffering from an injury in the Jacksonville ...

San Francisco 49ers QBs Mac Jones and Brock Purdy discussed their approach heading into Week 4 against the Jacksonville Jaguars, talked about their recovery and preparation, and highlighted how they ...

Rookie Travis Hunter, second-year wide receiver Brian Thomas Jr. and the Jacksonville Jaguars make the trip west to face the San Francisco 49ers in Week 4 NFL action at Levi's Stadium. Kickoff is 4:05 ...

San Francisco 49ers WR Ricky Pearsall goes for a one-handed catch, hauling in a 31-yard pass from QB Brock Purdy.

The 49ers have two turnovers. The Jaguars converted both into touchdowns. That’s the difference thus far as Jacksonville leads 17-6 at halftime.

One play into the second quarter, Brock Purdy hit ex-Jaguars tight end Luke Farrell on a first-down pass only to see ...

Highlights from the Week 4 matchup between the Washington Commanders and the Atlanta Falcons during the 2025 NFL season.