Once again, injuries are piling up for the 49ers, as several starters did not practice on Tuesday, which was the lone day this week before the game. That included quarterback Brock Purdy, wide receiver Ricky Pearsall, wide receiver Jauan Jennings, and defensive lineman Yetur Gross-Matos, among others.

Los Angeles vs. San Francisco takes place on Thursday Night Football, and bettors can use NFL promos at the best NFL betting sites and NFL betting apps

The Jacksonville Jaguars are a tough ball club. They've started the year 3-1 with victories against the Houston Texans and San Francisco 49ers in the last two w

An interesting new name has entered the fray as a pass rushing option for the San Francisco 49ers: New Orleans Saints defensive end Carl Granderson. With star pass rusher Nick Bosa down for the year with a torn ACL, there has been near-constant chatter ...

The San Francisco 49ers visit the Los Angeles Rams in Week Five of the 2025 NFL season. Get match details, betting tips, predictions and TV info for Thursday's game

Christian McCaffrey is the best fantasy football running back in the game right now and he is pacing to have a career year as a receiver. That is why there has not been as much attention on his struggles as a running back. While the San Francisco 49ers have struggled to run the ball as a team, McCaffrey may be at the heart of the issues.

The 49ers found brief momentum with 3 1/2 minutes to play, after Jaguars kicker Cam Little missed a 47-yard field goal. Trailing by five, the 49ers (3-1) took over on their own 29-yard line, but Purdy was sacked and fumbled shortly thereafter.

NFL Week 5 odds, picks, predictions, TV channel, streaming information for Thursday Night Football game between San Francisco 49ers, Los Angeles Rams.

Head Coach Kyle Shanahan said that 49ers safety Malik Mustapha could be back practicing with the 49ers after Week 6.

Find single game tickets to the Los Angeles Rams vs. San Francisco 49ers NFL Week 5 matchup on Thursday, October 2, 2025 at SoFi Stadium.

Matt Temple-Marsh previews Thursday's NFL action, with four bets for San Francisco 49ers against Los Angeles Rams. This is a heavyweight NFC West clash in Los Angeles — both teams arrive at 3–1 but on very different tracks.

Robert Saleh found himself in the headlines this past week. Ahead of their Week 4 game against the Jacksonville Jaguars, the San Francisco 49ers defensive coordinator called out Jags head coach Liam Coen's “sign-stealing”. After San Francisco lost the game, Coen and Saleh got into a heated argument where the two had to be separated.