The Indianapolis Colts' offensive line couldn't handle the Los Angeles Rams' pass rush in a frustrating Week 4 defeat.

San Francisco 49ers quarterback Brock Purdy (13) and offensive tackle Trent Williams (71) walk off the field after an NFL football game against the Jacksonville Jaguars in Santa Clara, Calif., Sunday, ...

NFL Network analyst Brian Baldinger and Chief National Reporter Steve Wyche discuss the impact of San Francisco 49ers injuries will have against the Los Angeles Rams defense ahead of the "Thursday ...

The 49ers will play a key NFC West game on Thursday night without their starting quarterback and both starting wide receivers. Pearsall has 20 catches for 327 yards on the season, while Jennings has ...

The Los Angeles Rams have started their season off strong. It is the team aspect that is getting it done early on and making sure they are doing all the right t ...

San Francisco 49ers quarterback Brock Purdy will sit out Thursday's Week 5 matchup with the Los Angeles Rams after re-aggravating an existing toe injury.

The Los Angeles Rams will try for their fourth straight win over the San Francisco 49ers when the NFC West foes meet on Thursday night.

LOS ANGELES -- The San Francisco 49ers' offense will be even more short-handed than it's been in the season's opening month when it takes on the Los Angeles Rams on Thursday night. On Wednesday, the ...

Quarterback Brock Purdy will miss his third game of the season because of an injury to his toe. The Niners (3-1) also ruled out starting receivers Ricky Pearsall and Jauan Jennings for the division ...

The FFHH crew breaks down their favorite futures bets at this point in the season, with Jay and Connor taking opposing views of the NFC hierarchy.

In his weekly Tuesday press conference, San Francisco 49ers coach Kyle Shanahan was asked about the team's challenging stretch of upcoming games, which features four road contests over the next five ...

The Los Angeles Rams are listing two offensive starters as doubtful to play against the San Francisco 49ers on Thursday Night Football, possibly opening the door for some others to prove worthy of ...