Buffalo Bills top New Orleans Saints in Week 4, 31-19
Digest more
Experts predict Dolphins vs Jets in Week 4
Digest more
The Buffalo Bills (3-0) host a struggling New Orleans Saints (0-3) squad on Sunday, September 28, 2025 at Highmark Stadium. The Saints have lost three games in a row. Date: Sept. 28
Here are the full inactive lists for the Buffalo Bills and New Orleans Saints ahead of their Week 4 game on Sunday at Highmark Stadium:
Preview the New Orleans Saints' NFL Week 4 matchup with the Bills, including live stream, TV channel, odds, and game information.
8hon MSN
QB Josh Allen leads Bills to 4-0 start, but concerns linger after close call in win over Saints
High expectations have their price, leaving Josh Allen and the Buffalo Bills unhappy, but relieved, following a close call against the winless New Orleans Saints.
Here are your Five Things to Know about the New Orleans Saints for Monday, September 29: 1. The New Orleans Saints fell in a 31-19 loss in Week 4 against the Buffalo Bills. Catch up on all the action, stats and reactions in our Game Center at NewOrleansSaints.com.
Buffalo is a 14.5-point favorite in the latest Saints vs. Bills odds from SportsLine consensus, while the over/under for total points scored is 48. The Bills are -1562 money line favorites (risk $1,562 to win $100),