Kyle Shanahan is 10-6 all-time against Sean McVay. Sean McVay has the upper hand in the postseason, beating Shanahan's 49ers en route to their championship in 2021.

The 49ers saw wide receiver Ricky Pearsall depart with an injury against the Jaguars. Afterwards, Kyle Shanahan updated Pearsall's status.

Head coach Kyle Shanahan told reporters on Monday that quarterback Brock Purdy’s toe issue that kept him out of sidelined for Weeks 2 and 3 flared up.

Brock Purdy returned to action in Week 4 in the 49ers' matchup vs. the Jaguars after missing the previous two weeks with a left shoulder injury and toe injury he suffered during Week 1. However, it sounds like playing on Sunday may have re-aggravated his toe injury.

Wide receiver Ricky Pearsall is the latest key member of the 49ers to be hit by the injury bug after hurting his knee in Week 4.

Kyle Shanahan revealed that the referees botched the enforcement of a penalty during the 49ers' loss to the Jaguars.

The San Francisco 49ers left their Week 4 battle with the Jacksonville Jaguars even more injured. Head coach Kyle Shanahan had

Arizona’s 24-23 win on Oct. 6 of last season, a game in which the 49ers led 23-10, helped chart the path to a 6-11 season.