The San Francisco 49ers can't catch a break in their offensive backfield. It started in training camp when running back ...

Reporting emerged earlier on Thursday noting that 49ers running back Isaac Guerendo is unlikely to play in Sunday's game ...

The 49ers will have to start their fourth different running back this Sunday against the Miami Dolphins. That's because ...

The San Francisco 49ers are poised to unveil their fourth starting running back of the season Sunday. The latest next man up ...

The other running backs on the 49ers' 53-man roster are Patrick Taylor Jr. and Israel Abanikanda. Taylor is expected to get ...

Well this isn't good. 49ers rookie Isaac Guerendo is nursing a new injury. Kyle Shanahan revealed Guerendo was held out of ...

Curious to know about 49ers RB Isaac Guerendo‘s injury? The standout rookie has drawn attention for his breakout performances ...

The rookie running back did not practice last week and has been officially ruled out of Sunday’s clash at Hard Rock stadium ...

San Francisco 49ers running back Isaac Guerendo. / Bob Kupbens-Imagn Images The San Francisco 49ers are already down Jordan Mason and Christian McCaffrey in their backfield (both are on injured ...

The San Francisco 49ers face the Miami Dolphins this weekend and the rookie running back is now a major doubt to take part.

San Francisco 49ers running back Isaac Guerendo is "unlikely to play" against the Miami Dolphins, according to ESPN insider ...

Isaac Guerendo faces an uphill climb if he wants to suit up on Sunday vs. the Dolphins after suffering a hamstring injury ...