College football odds, picks, predictions for Week 5, 2025
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The No. 21 USC Trojans are slowly climbing the AP Top 25 Poll after a 4–0 start, and one analyst believes their season will be defined a looming five-game Big Ten gauntlet that could decide their College Football Playoff hopes.
Halftime in Clemson will be extended due to lightning being detected in the area within eight miles of the stadium. Syracuse leads Clemson 24-14 in the latest stunning scoreline involving the Tigers, and both teams will have some additional time to make adjustments and get ready for the second half due to weather in the area.
The No. 9 Illinois Fighting Illini, led by quarterback Luke Altmyer, face the No. 19 Indiana Hoosiers, led by quarterback Fernando Mendoza, on Saturday, Sept. 20, 2025 at Memorial Stadium in Bloomington,
No. 11 Oklahoma beat No. 22 Auburn, No. 19 Indiana destroyed No. 9 Illinois, and No. 17 Texas Tech ripped No. 16 Utah. Plus, Miami beat up Florida in a rivalry game, and Michigan knocked off Nebraska in the Big Ten.