Los Angeles is a 6.5-point favorite in the latest Chargers vs. Giants odds from SportsLine consensus, while the over/under for total points scored is 43.5. The Chargers are -297 money line favorites (risk $297 to win $100),

The Chargers defense then rose to the challenge as the Giants faced first-and-goal at the 4 but came away with no points. Tuli Tuipulotu came up with a massive run stop on third-and-goal at the 1 before the Chargers forced an incompletion for a turnover on downs.

Highlights from the Week 4 matchup between the Los Angeles Chargers and the New York Giants during the 2025 NFL season.

Welcome to the Week 4 grades! The New York Giants' decision to bench Russell Wilson is looking like a brilliant one after Sunday's action. In his first career start, rookie Jaxson Dart went out and led the Giants to one of the biggest upsets of the 2025 season.

Center Bradley Bozeman (back) and safety Elijah Molden (hamstring), meanwhile, are both active after being listed as questionable. The Chargers play the New York Giants on Sunday with kickoff at 10 a.m. (PT) from MetLife Stadium. The Chargers-Giants betting line shows the Bolts are the favorites on Sunday.

On defense, the Giants of course have their insane defensive line of Brian Burns, Kayvon Thibodeaux, Dexter Lawrence and rookie Abdul Carter. Burns is tied for second in the NFL with four sacks. They didn't finish at the quarterback as much as they would've liked against Kansas City, but were in the backfield on numerous occasions.

They say you have to "look the part to be the part" and CBS sideline reporter Melanie Collins does just that during her NFL assignments. For Week 4, Collins was on assignment at MetLife Stadium for the New York Giants' stunning upset win over the Los Angeles Chargers.