The Arizona Cardinals were dealt a rough hand against the San Francisco 49ers on Sunday, and a tight loss was the least of their worries. It was simply a night

Arizona Cardinals running back James Conner was taken off the field with a right ankle injury during Sunday's loss to the San Francisco 49ers.

James Conner exited the Arizona Cardinals' Week 3 matchup with the San Francisco 49ers with a lower leg injury. He was carted to the locker room.

But not all is lost, depending on how you look at the situation.

Arizona Cardinals running back James Conner has been taken off the field with a right ankle injury during Sunday's game against the San Francisco 49ers.

Our best guess as of Wednesday afternoon is that Carter will handle the majority of the early downs, while Demercado will stay in his third-down and two-minute role. Cardinals running backs have averaged 16.