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Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...

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For the past decade, scientists have relied almost exclusively on CRISPR-Cas systems for genome editing. Now, a smaller but equally efficient nuclease is here to compete.

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2022). Similarly, systematic evaluation of single-cell transcription regulation maps in cynomolgus monkeys and other non-human primate models compared to humans highlights differences in cell ...

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. *Corresponding Author: Max S. Wicha, Department of Internal Medicine, University of Michigan–Ann Arbor, 2800 Plymouth Road ...