The San Francisco 49ers overhaul of their defensive line is set to include the release of perhaps their best defensive tackle ...

The Detroit Lions and San Francisco 49ers play Monday, Dec. 30, at the 49ers' Levi's Stadium in a game on the NFL Week 17 schedule. Which team will win the Monday Night Football game? Check out ...

A rematch of last year's NFC Championship Game, the Detroit Lions vs. San Francisco 49ers was expected to be one of the best games of the season when the schedule was released. Now though ...

The San Francisco 49ers suffered a frustrating 29-17 loss to the Miami Dolphins at Hard Rock Stadium, as penalties undermined their chances to secure a critical win in the playoff race.

The 49ers can still make the playoffs, but they need a lot of things to go their way. The most important would be that they win this week. Brock Purdy will be under center, and he needs to find a ...

The San Francisco 49ers are moving on from a player who many questioned why he was still on the roster. Ambry Thomas, a 3rd-round pick in the 2021 NFL Draft out of Michigan was waived by the ...

The San Francisco 49ers signed Wooten for their practice squad on Tuesday. Wooten joins the 49ers after the team suspended linebacker De’Vondre Campbell for its remaining three regular-season games.

Pro Football Hall of Famer Jerry Rice called out San Francisco 49ers star Deebo Samuel for his crucial mistakes in the team’s 12-6 loss to the Los Angeles Rams last week. Samuel had three ...