The San Francisco 49ers have some talent along their defensive line, but they could use more, and that could come early in ...

San Francisco 49ers nickel back Upton Stout revealed the toughest wide receiver he has faced during his rookie NFL season.

For the first time since joining the San Francisco 49ers in 2022, Christian McCaffrey will face his former team, the Carolina ...

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale ...

The San Francisco 49ers are starting to make adjustments to their roster as they head into a playoff push. That means ...

Call Sunday’s Niners-Cardinals showdown the Battle of Wounded Knee… and Leg, and Shoulder, and Feet, and even Appendixes. You ...

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are ...

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest ...

Jacoby Brissett completed an NFL-record 47 passes, but San Francisco's offense rolled in Purdy's first game in weeks.

The final selection of the 2022 NFL Draft, Purdy became the starting quarterback as a rookie after the 49ers lost Jimmy ...

The San Francisco 49ers (6-4) visit the Arizona Cardinals (3-6) Sunday in Week 11. Kickoff from State Farm Stadium in ...

And while the team’s offense seems to be getting back to full strength, star wideout Brandon Aiyuk has yet to make his season ...