Here are five takeaways from the loss: The Cardinals defense gave the offense every chance. With 3:15 to play, Calais ...

Somehow the San Francisco 49ers figured out a way to leave their home opener with a victory over the Arizona Cardinals. Here ...

The San Francisco 49ers face the Arizona Cardinals on Sunday, Sept. 21, 2025 in Week 3 of the NFL season at State Farm ...

In a slugfest in Santa Clara, The Arizona Cardinals lost to the San Francisco 49ers 16-15 on a last-second field goao, but it ...

QB Trevor Lawrence spoke to the media Wednesday as the Jaguars prepared to play the San Francisco 49ers at Levi’s Stadium in Santa Clara, Calif., Sunday: “This scheme has always been really good and ...

The Jaguars face Kyle Shanahan’s 49ers in a test of discipline and execution. Can Trevor Lawrence and Liam Coen deliver?

It's a big week for the Arizona Cardinals and quarterback Kyler Murray. Murray, who will look to guide Arizona to a 3-0 start to the season, are roa ...

TEMPE — The San Francisco 49ers won’t be the only force going against the Arizona Cardinals this week. Adversity has taken centerstage and will be a key component in Sunday’s matchup in Santa Clara as ...

Seattle loses for the seventh time in eight meetings with its NFC West rival, on a day the Seahawks could be built for.