A team of chemists has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study combines biocatalytic carbon-hydrogen oxidation ...

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases, including ...

Researchers have successfully developed a modular synthetic translational coupling element (SynTCE), significantly enhancing ...

Scientists have discovered a key protein that helps cancer cells avoid detection by the immune system during a type of ...

Researchers at McMaster University, Canada, have identified a critical biological mechanism involving the protein MANF ...

Lin said that in a hypoxic tumor microenvironment, cancer cells secrete hydrogen sulfide and send a signal to the tetrameric ...

Scientists are tapping powerful AI to predict how proteins interact — a tall order even for AI — in the stubborn, fascinating ...

RNA-targeting compounds or small interfering RNAs (siRNAs) offer a potent means for controlling viral infections. An essential prerequisite to their design depends on identifying conserved and ...

Tesamorelin, a synthetic peptide analog of growth hormone-releasing hormone (GHRH), has recently garnered attention for its unique biochemical properties and intriguing impact on various physiological ...

Scientists at City of Hope have collared a tricky culprit that helps cancer cells evade CAR T cell therapy. CAR T cell ...

Scientists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S.