Jamie Lee Curtis has been "clean and sober" for a quarter ... "For all those struggling with addiction and shame, there are others out here who care. My hand in yours. Our hands in yours.

The actor has opened up about her decade-long addiction to painkillers in a powerful new interview. At the time of filming the movie, Curtis ... Jamie, I see you. I see you with your little pills ...

Jamie Lee Curtis, a Hollywood heavyweight ... She battled alcoholism and developed an addiction to painkillers after using them to manage post-surgery pain from a cosmetic procedure.