Lineup notes on who's in, who's out and which fantasy football starters are questionable for this weekend's games.

Isaac Guerendo hasn't started a game at running back since the fourth grade. Now he's the 49ers starting running back for the remainder of the season. Here's the good news for the 49ers: In 42 career ...

On the other side of the ball, Isaac Guerendo has been ruled out due to ... but it's worth noting this was a light workout. For his part, Mahomes indicated he planned to push it in practice ...

Linebacker Dre Greenlaw was back at practice in a limited capacity on Wednesday following his Week 15 regular season debut.

Then they try to have a workout on Sunday to see that ... San Francisco 49ers running back Isaac Guerendo was nominated for the Pepsi Zero Sugar Rookie of the Week Award for Week 14 after scoring ...

As Week 14 begins in the NFL, the league is starting to enter the home stretch of the season. The games are more important ...

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until ...

Isaac Guerendo faces an uphill climb if he wants to suit up on Sunday vs. the Dolphins after suffering a hamstring injury ...

The San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday at the Miami Dolphins, a source told ESPN's Adam Schefter on Thursday.

The San Francisco 49ers got a great performance out of rookie running back Isaac Guerendo in his first career NFL start in Week 14 against the Chicago Bears. However, the fourth-round rookie ...