San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the ...

San Francisco 49ers rookie RB Isaac Guerendo suffered MCL and ankle sprains against the Arizona Cardinals, avoiding an ACL injury.

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The ...

That was until Isaac Guerendo showed up. The rookie fourth-round pick in 2024 stepped into action on Sunday in Week 14, dominating the Bears to the tune of 128 total yards and two touchdowns.

Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallares of the 49ers' ...

Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

The San Francisco 49ers got a great performance out of rookie running back Isaac Guerendo in his first career NFL start in Week 14 against the Chicago Bears. However, the fourth-round rookie ...

Things only worsened during the win against the Chicago Bears. Fourth-string running back Isaac Guerendo, who drew the start in the absence of his aforementioned teammates, exited the game during ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and was questionable to return in Sunday's matchup with the Chicago Bears. More News: Chargers Make Game-Time ...

The latest injury update for San Francisco 49ers running back Isaac Guerendo in Week 15 against the Los Angeles Rams. San Francisco 49ers running back Isaac Guerendo. / Bob Kupbens-Imagn Images ...

Yet another San Francisco 49ers running back seems set to miss some action, as ESPN insider Adam Schefter reports “it looks as if” Isaac Guerendo will miss Sunday’s matchup against the Miami ...

SANTA CLARA — In the 49ers' 38-18 win over the Chicago Bears on Sunday, rookie running back Isaac Guerendo had a little bit of a scare, leaving the game with a foot injury in the fourth quarter.