That was until Isaac Guerendo showed up. The rookie fourth-round pick in 2024 stepped into action on Sunday in Week 14, dominating the Bears to the tune of 128 total yards and two touchdowns.

According to ESPN's Adam Schefter, San Francisco 49ers rookie running back Isaac Guerendo is expected to suit up for Thursday ...

Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

The San Francisco 49ers got a great performance out of rookie running back Isaac Guerendo in his first career NFL start in Week 14 against the Chicago Bears. However, the fourth-round rookie ...

The latest injury update for San Francisco 49ers running back Isaac Guerendo in Week 15 against the Los Angeles Rams. San Francisco 49ers running back Isaac Guerendo. / Bob Kupbens-Imagn Images ...

Things only worsened during the win against the Chicago Bears. Fourth-string running back Isaac Guerendo, who drew the start in the absence of his aforementioned teammates, exited the game during ...

San Francisco 49ers running back Isaac Guerendo, sidelined for last Sunday's game against the Miami Dolphins due to hamstring ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and was questionable to return in Sunday's matchup with the Chicago Bears. More News: Chargers Make Game-Time ...

Yet another San Francisco 49ers running back seems set to miss some action, as ESPN insider Adam Schefter reports “it looks as if” Isaac Guerendo will miss Sunday’s matchup against the Miami ...

Guerendo (foot) is listed as active Thursday against the Rams, Lindsey Pallares of the 49ers' official site reports. Guerendo came out of this past Sunday's win versus the Bears with a sprained ...

Guerendo (foot) is listed as questionable for Thursday's game versus the Rams, Eric Branch of the San Francisco Chronicle reports. Despite operating on a short week between games, the 49ers are ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac Guerendo with some Patrick Taylor Jr. thrown in for good measure and it was ...