Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

Coach Kyle Shanahan said after Sunday's 38-13 win over the Bears that Guerendo possibly has a foot sprain, Eric Branch of the San Francisco Chronicle reports. Guerendo exited in the fourth quarter ...

Things only worsened during the win against the Chicago Bears. Fourth-string running back Isaac Guerendo, who drew the start in the absence of his aforementioned teammates, exited the game during ...

A former track standout and converted wide receiver, Guerendo rushed 14 times for 85 yards and a touchdown and added 17 yards on three receptions as San Francisco took care of Dallas. Isaac ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and was questionable to return in Sunday's matchup with the Chicago Bears. More News: Chargers Make Game-Time ...

SANTA CLARA — The 49ers' NFC matchup with the Chicago Bears on Sunday will be Isaac Guerendo’s chance to shine. The rookie running back has had few chances to show what he is capable of in his ...

SANTA CLARA — When Isaac Guerendo trots onto the field with the first team Sunday at Levi’s Stadium, he will equal the same number of starts he had in five years of college football.

SANTA CLARA, Calif. -- As the first quarter wound down in his second NFL game, San Francisco 49ers running back Isaac Guerendo trotted on to the field, stepped into the huddle and listened ...

Guerendo has averaged an impressive 5.9 yards per carry this season, aided by his ability to break off big runs. On 42 carries, he has totaled 246 rushing yards and two touchdowns, averaging 3.1 ...

Both players will be placed on Injured Reserve and will be out for the season. That means rookie Isaac Guerendo will be the starter for the remainder of the season. Guerendo has shown flashes this ...