The San Francisco 49ers likely will be without rookie running back Isaac Guerendo for Sunday’s game against the Miami Dolphins.

Rookie running back Isaac Guerendo scored from a yard out with 1:39 left in the first quarter and the 49ers are up 14-0 at Levi’s Stadium. Guerendo set up his score with a 27-yard catch from ...

LATEST Dec. 8, 4:15 p.m. New 49ers starting running back Isaac Guerendo didn't even complete his first game as the feature back before exiting with an injury, continuing a nightmare-like season ...

Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

The San Francisco 49ers are reportedly expected to lean on rookie running back Isaac Guerendo for the remainder of the 2024 regular season. According to ESPN, Guerendo is preparing to "carry a ...

SANTA CLARA, Calif. -- As the first quarter wound down in his second NFL game, San Francisco 49ers running back Isaac Guerendo trotted on to the field, stepped into the huddle and listened ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities to show what he can do as a runner. Now with Christian McCaffrey and ...

Isaac Guerendo hasn't started a game at running back since the fourth grade. Now he's the 49ers starting running back for the remainder of the season. Here's the good news for the 49ers ...

The 49ers lost both first-string running back Christian McCaffrey and second-string running back Jordan Mason to injuries last week in Buffalo, leaving only rookie Isaac Guerendo available.

Swift should find success -– especially if he can find his way into the end zone. This week, Guerendo and the M.A.S.H. unit Niners host a Bears defense that has been running back-friendly recently.

Next in line: rookie Isaac Guerendo, a Louisville product who has seen just 42 carries this season. He's averaged 5.9 yards per rush, gaining 246 yards and scoring two touchdowns -- including one ...