The San Francisco 49ers will reportedly likely be without yet another running back for Sunday's game against the Miami ...

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

Los Angeles Rams outside linebacker Byron Young engulfs San Francisco 49ers running back Isaac Guerendo on an authoritative tackle for a loss in the rain.

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

San Francisco 49ers RB Isaac Guerendo sped past the Buffalo Bills defense for a touchdown on "SNF" San Francisco 49ers RB ...

San Francisco 49ers running back Isaac Guerendo's second touchdown of day gets 49ers to 30-point mark vs. Chicago Bears.

San Francisco 49ers rookie RB Isaac Guerendo punched in a touchdown in the team's Week 14 matchup against the Chicago Bears.

they turned to rookie Isaac Guerendo with some Patrick Taylor Jr. thrown in for good measure and it was one of the highlights of a 38-13 win over the Chicago Bears Sunday at Levi’s Stadium.

A 38-13 victory over the woeful Chicago Bears ended the 49ers’ three-game losing streak, but now an extended win streak must ...

they turned to rookie Isaac Guerendo with some Patrick Taylor Jr. thrown in for good measure and it was one of the highlights of a 38-13 win over the Chicago Bears Sunday at Levi’s Stadium.