By putting a carbon atom in place of a core oxygen, chemists constructed an opioid that blocks pain with less respiratory ...

Saffron (Crocus sativus L.) is a highly valued spice with potent antioxidant, anti-inflammatory, neuroprotective, and ...

1 Introduction Sulfa drugs, commonly known as sulfonamides, encompass a significant functional group exhibiting distinctive biological activities (Boufas et al., 2014). Apart from medicinal ...

The Journal of Medicinal Chemistry is pleased to present its latest Drug Discovery Collection, this time dedicated to contributions from Czechia. Czechia (and former Czechoslovakia) has a long ...

A series of diaryl piperidone-sulfonamide derivatives were designed as dual inhibitors of STAT3/CAIX and ferroptosis inducers for triple-negative breast cancer (TNBC).