Warsaw breakage syndrome (WABS) is caused by defective DDX11, a DNA helicase that is essential for chromatid cohesion. Here, a paired genome-wide siRNA screen in patient-derived cell lines reveals ...

Meiosis is a key event for stable sexual reproduction using a unique form of a cell division to generate haploid recombined gametes. It comprises one round of DNA replication followed by two rounds of ...

The bystander effect for sister chromatid exchanges (SCEs) and chromosomal aberrations was examined in hamster cell lines deficient in either DNA-PKcs (V3 cells, deficient in nonhomologous end joining ...

Tokyo, Japan – Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural ...

Methods are described for the short-term culture (48 to 56 h) of lung, liver, and kidney cells from C57B1/6 mice. With these techniques, mice can be exposed in vivo to test compounds and the cells ...

Scientists reveal a surprising new role for tDNAs and RNA polymerase III-associated proteins in sister chromatid cohesion. Sister chromatid cohesion (the binding together of the two identical copies ...

Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural network (CNN) with ...

Since sister chromatids are identical to each other, recombination with a sister chromatid is expected, in most cases, to be a precise way for repairing DNA damage. Recombination between 2 different ...

Ants supply microbes, acids, and enzymes to produce a yogurt with distinctive textures and flavors, bridging folklore and modern food science. Who Will Win the 2025 Nobel Prize? Scientists Make Their ...

DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to ...