A new tool for understanding chromosome abnormalities in the eggs of older women

Human egg cells are often prone to chromosomal errors. As women age, the error rate increases sharply—and can contribute to ...
Europe PMC

The mutational dynamics of the Arabidopsis centromeres

Centromeres are specialized chromosome regions essential for sister chromatid cohesion and spindle attachment during mitosis. Many centromeres comprise highly variable, megabase-scale satellite DNA ...
PNAS

Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex

The Cohesin complex is placed at the heart of many DNA-based processes including sister chromatid cohesion and chromatin loop extrusion. The Cohesin release factor Wapl opens the DNA exit gate in ...
The EMBO Journal

A chromatin-remodeling-independent role for ATRX in protecting centromeric cohesion

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Sister-chromatid cohesion mediated by the ...
GitHub

goplot does not find ontology

> data(geneList, package = "DOSE") > de <- names(geneList)[1:100] > yy <- enrichGO(de, 'org.Hs.eg.db', ont="BP", pvalueCutoff=0.01) > head(yy) ID Description ...
GEN

Directional Genomic Hybridization (dGH): A Powerful Technique for Assessing Structural Variants

Assessments of DNA misrepair, and the resulting effects on the structural integrity of the genome, are critical for evaluating the safety of cell and gene therapy applications. Most genome editing ...
C&EN

Development of MPS1 Inhibitors: Recent Advances and Perspectives

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
IEEE

Detection model of sister chromatid cohesion defects based on Vision Transformer

Abstract: To evaluate the function of cohesin and its regulators, classifications of chromosomes based on the positional relationship between sister chromatids are used. Although the analysis has been ...
istockphoto

Chromatid stock illustrations

Human chromosomes (human normal karyotype). Humans have 23 pairs of chromosomes, with one set inherited from each parent. The main difference between the karyotype of a female and a male lies in the ...
News Medical

Using convolutional neural network to automate the identification of chromatid cohesion defects

Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural network (CNN) with ...
EurekAlert!

Neural network learns how to identify chromatid cohesion defects

Tokyo, Japan – Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural ...