Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. To obtain further insight into the roles of ...
Cardiac progenitor cells (CPCs) in the adult heart are used for cell-based treatment of myocardial damage, but factors determining stemness, self-renewal, and lineage commitment are poorly understood.
The Cohesin complex is placed at the heart of many DNA-based processes including sister chromatid cohesion and chromatin loop extrusion. The Cohesin release factor Wapl opens the DNA exit gate in ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Sister-chromatid cohesion mediated by the ...
> data(geneList, package = "DOSE") > de <- names(geneList)[1:100] > yy <- enrichGO(de, 'org.Hs.eg.db', ont="BP", pvalueCutoff=0.01) > head(yy) ID Description ...
Assessments of DNA misrepair, and the resulting effects on the structural integrity of the genome, are critical for evaluating the safety of cell and gene therapy applications. Most genome editing ...
Abstract: To evaluate the function of cohesin and its regulators, classifications of chromosomes based on the positional relationship between sister chromatids are used. Although the analysis has been ...
Previous studies indicated that mitotic chromosome structure consists of many stacked layers formed by a mononucleosome sheet folded as a helicoid. This multilayer chromatin structure justifies the ...
Human chromosomes (human normal karyotype). Humans have 23 pairs of chromosomes, with one set inherited from each parent. The main difference between the karyotype of a female and a male lies in the ...
Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural network (CNN) with ...
Tokyo, Japan – Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural ...
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