Rec8 joins the whole length of the sister chromatids together, and, as meiosis proceeds, is lost in a stepwise manner that correlates with the loss of sister-chromatid cohesion. Figure 1 ...

the postulate that a break at a particular level in one chromatid under strain induces a break in a non-identical chromatid at precisely the same spot due to transfer of stress. In regard to (1 ...

By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...

Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Genomes are organised into DNA loops by the ...

7 Division of Neurosurgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA Correspondence to Dr Clark C Chen, Director of Clinical Neuro-oncology, Attending Neurosurgeon, Beth Israel ...