Here are five takeaways from the loss: The Cardinals defense gave the offense every chance. With 3:15 to play, Calais Campbell earned a safety on a holding penalty, putting Arizona up, 15-13. All the offense had to do was pick up a few first downs and run out the clock.

Bosa appeared to injure his knee late in the first quarter, while Conner left with an ankle injury after a short run in the third.

Who won the Arizona Cardinals vs San Francisco 49ers game? Check out our updates, highlights and analysis from the NFL Week 3 game.

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The Arizona Cardinals offense squandered opportunity after opportunity in a 16-15 loss to the San Francisco 49ers. They fell to 2-1 with the defeat.

Take a look at which facets of the Cardinals' performance saw their stocks rise and fall in the heartbreaking defeat in San Francisco.

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Thompson finished Sunday's 16-15 loss to the 49ers with six tackles (four solo). Thompson played every single defensive snap for a third consecutive week and finished tied with Budda Baker for third most tackles on the team. Thompson is up to 24 total tackles on the season, which is second on the Cardinals behind linebacker Mack Wilson (28).

Rice rode its spread-option offense to a convincing win over Charlotte, and the 49ers lost starting QB Conner Harrell to injury.

Eddy Pineiro drilled a 35-yard field goal as time expired to lift the San Francisco 49ers to a 16-15 win over the Arizona Cardinals on Sunday afternoon in Santa Clara, Calif.