Rams coach Sean McVay opts to rest Matthew Stafford, giving Jimmy Garoppolo his first start with the team against Seattle.

See what Kyle Shanahan, Brock Purdy, Dan Campbell and Jared Goff had to say following the Week 17 primetime contest.

ESPN's cameras caught San Francisco 49ers general manager John Lynch raging at his team during Monday night's loss to the ...

QB Brock Purdy faces elbow injury scare in loss to Lions, but initial tests show no damage to surgically repaired UCL.

Somehow, the San Francisco 49ers playoff hopes are alive. It may feel absurd to believe that with a 6-8 record, the 49ers are clinging to a less than one percent chance to squeak in as the seventh ...

It's been a disappointing season for both the San Francisco 49ers and Miami Dolphins. Each team came into the year with playoff expectations, but heading into Week 16, both teams have been all but ...

San Francisco 49ers left tackle Trent Williams, who has missed his team's last four games with an ankle injury, may sit the remainder of the season. <a href="https ...

The San Francisco 49ers plan to part ways with linebacker De'Vondre Campbell. Head coach Kyle Shanahan said during a conference call on Friday that the 49ers are making preparations to move on ...

SANTA CLARA, Calif. — The San Francisco 49ers still have plenty of talent. They still have plenty of good coaches. The missing element in their disappointing season so far, the team decided in t ...

Rookie running back Isaac Guerendo left late in the fourth quarter of the 49ers' 38-13 win over the Chicago Bears with a foot injury, according to head coach Kyle Shanahan. The 49ers will learn ...