Christian McCaffrey is dealing with another long-term injury again. The San Francisco 49ers running back went down with a knee injury during the second quarter of the team's "Sunday Night Football ...

The San Francisco 49ers aim to improve their 5-7 record in Week 14 when they take on the Chicago Bears. However, injury woes have plagued the roster, with the regular season approaching an end.

We used our Cricut to make DIY wall stencils for our ... were a new investor today — here are 3 of his simple strategies 49ers LB De'Vondre Campbell refuses to enter game after losing his ...

The San Francisco 49ers' season has been on the brink for weeks, and the Week 13 blowout loss to the Buffalo Bills certainly didn't help their playoff chances. They have more than enough injuries ...

San Francisco 49ers player Trent Williams and his wife Sondra are mourning the passing of their newborn son, the couple revealed on Monday. "It's been extremely hard trying to process the saddest ...

49ers left tackle Trent Williams’ wife Sondra announced the tragic death of their newborn son, Trent Jr. In a post on Instagram on Sunday, Sondra revealed that she lost Trent Jr.’s twin early ...

Orchard Park, N.Y. — The Buffalo Bills dominated the San Francisco 49ers on a snowy night at Highmark Stadium, winning 35-10 and clinching the AFC East title for the fifth consecutive season.

San Francisco 49ers star Christian McCaffrey left Sunday night’s 35-10 loss to the Buffalo Bills with a knee injury, but it appeared to be much worse than that. McCaffrey is believed to have ...

The San Francisco 49ers are in dire straights after a blowout loss to the Buffalo Bills, and QB Brock Purdy knows it. San Francisco dropped to 5-7 after a 35-10 defeat in Buffalo. After the major ...

Check out these NFL Week 14 picks and NFL Week 14 predictions for the game, which can be seen at 2:25 p.m. MST on FOX (stream with free trial from FUBO). The 49ers are a 4-point favorite over ...

The San Francisco 49ers were met with a winter snowstorm at Highmark Stadium in Week 13 as they battled it out with the Buffalo Bills. Light flurries were falling during pregame warmups ...

So, it might not be a surprise that they easily defeated the San Francisco 49ers on Sunday night. As snow fell throughout the game at Highmark Stadium, the Bills took down the 49ers, 35-10.