After missing the San Francisco 49ers' first eight games of the campaign, superstar running back Christian McCaffrey made his season debut in his team's hard-fought Week 10 win over the Tampa Bay ...

Christian McCaffrey is dealing with another long-term injury again. The San Francisco 49ers running back went down with a knee injury during the second quarter of the team's "Sunday Night Football ...

The San Francisco 49ers released a statement on the passing of Trent Williams’ son. “The 49ers mourn the passing of Trent Williams' son and send him and his family all our love,” the 49ers ...

Puka Nacua continues to prove that his historic rookie season was no fluke. When on the field, he is one of the best wide ...

Brandon Allen surfaced to throw the interception. Jake Tonges on the field for the 49ers now. Former Bears tight end. Tarvarius Moore with a late hit on a punt. What's an illegal hit between friends?

THE BUFFALO BILLS ... The Bills dashed through the snow ... and past the 49ers, 35-10, in a game that saw and Josh Allen throw a touchdown to himself (kinda) and become just the second ...

The Chicago Bears and San Francisco 49ers play on Sunday, Dec. 8 at the 49ers' Levi's Stadium in a game on the NFL Week 14 schedule. Which team will win the NFL Week 14 game? Check out these NFL ...

The main roads into Orchard Park were traversable early Sunday morning, about 12 hours before the Buffalo Bills and San Francisco 49ers face off in the chilly confines of Highmark Stadium.

A good ol' fashioned lake effect snowstorm is burying western New York this weekend when the Buffalo Bills and San Francisco 49ers faceoff at Highmark Stadium on Sunday night. UPDATED SUNDAY ...

As he approaches the end of his contract, one San Francisco 49ers star could leave to join a familiar face in the AFC East. The 49ers will have several key personnel decisions to make at the end ...

FOX 11 reached out to the 49ers to see if they were going to do anything. After we interviewed De La Rosa, a team official sent us an email saying the team had shipped out a signed helmet.

San Francisco 49ers George Kittle lost a bet as he was seen wearing UCLA gear while speaking to reporters on Thursday. Kittle had on a gold UCLA helmet with a blue sweater, and it came after UCLA ...