The San Francisco 49ers (6-10) are 4.5-point underdogs as they try to break their three-game losing streak in a matchup ...

The San Francisco 49ers missed the playoffs entirely after making it to the Super Bowl last season. They will have some big ...

While the San Francisco 49ers chances of a spot in the playoffs have been decided for some time now, their loss in Week 18 to ...

What channel is 49ers vs Cardinals game on today? How to watch San Francisco vs Arizona NFL Week 18 football game on TV, ...

The Detroit Lions could have rested their starters on Monday night against the San Francisco 49ers with the knowledge that it ...

And don't be surprised if the Lions-Vikings winner-take-all finale smashes the Sunday Night Football high mark for this year, ...

After three straight seasons of long playoff runs, the San Francisco 49ers are packing up and heading home early for a change ...

Members of the San Francisco 49ers on Monday began the process of boxing up personal belongings in their lockers ahead of the ...

Pearsall missed the first six games of his rookie season due to being shot in a robbery. He is looking to make amends with ...

Drawing inspiration is always a powerful tool. It's prevalent among NFL players and coaches, especially for 49ers cornerback Deommodore Lenoir. On Monday during ...

DFS millionaire Mike McClure shares his top daily Fantasy football picks for San Francisco 49ers vs. Detroit lions on MNF ...