This work presents valuable new data on the role of D-Serine and how it competes with its stereoisomer L-Serine to influence metabolism. The work presents a variety of solid experimental data combined ...

While numerous researchers claim that the minimization of prediction error (PE) is a general force underlying most brain functions, others argue instead that PE minimization drives low-level, ...

The ALBORADA Drug Discovery Institute, University of Cambridge, Cambridge, United Kingdom ...

Long-term 17α-estradiol modulates aged male hypothalamic function via HPG axis and energy metabolism, mitigating aging-related neuronal changes.

GFP knockin mouse tissue and ultra-fresh synaptonerosomes indicate that the postsynaptic density is a not a conserved feature of glutamatergic synapses in the mouse brain.

Structural and computational approaches uncover the molecular basis for dimerization, open-closed conformational transitions, and the dynamic behavior of the human angiotensin-I converting enzyme ...

In this important work, the authors present a new transformer-based neural network designed to isolate and quantify higher-order epistasis in protein sequences. They provide solid evidence that higher ...

Deep transfer learning methodologies reveal hidden heterogeneity in β-cells driven by type 2 diabetes and obesity.

A combination of cryogenic electron microscopy and molecular simulations has been used to study the structure and dynamics of an enzyme called ACE.

Stimulation of the A13 brain region restores motor function in Parkinson's disease mouse models by alleviating bradykinesia and akinesia.

The objects that migrants carry with them are tethers to the lives they have left behind.

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States ...