The Super Bowl champion Eagles clash with the Buccaneers in Tampa in a battle of undefeated teams; The winless Jets and ...

Even without Brock Purdy, the San Francisco 49ers were able to get it done. Quarterback Mac Jones led the way as the 49ers ...

The San Francisco 49ers will look to start their season 4-0 for the second time under head coach Kyle Shanahan.

The San Francisco 49ers have overcome injuries to star players to pull out three straight wins to open the season in games that weren't decided until the closing minutes. The latest came when backup ...

Trevor Lawrence, Travis Hunter and the Jacksonville Jaguars go west to face the San Francisco 49ers in Week 4 NFL football. See updates and analysis.

The 49ers found brief momentum with 3 1/2 minutes to play, after Jaguars kicker Cam Little missed a 47-yard field goal.

The San Francisco 49ers struggled in their home opener, but they left Week 3 with a win vs. the Arizona Cardinals. Here are ...

NFL Week 4 odds, picks, predictions, TV channel, streaming information for Sunday football game between Jacksonville Jaguars and San Francisco 49ers.

Kyle Juszczyk of the San Francisco 49ers celebrates after a touchdown against the Arizona Cardinals with teammate Ricky ...

Kyle Juszczyk's wife Kristin and George Kittle's wife Claire shared a funny fashion moment on Sunday before the San Francisco 49ers' Week 3 game.

Micah Parsons’ much-anticipated return to Dallas to face his former Cowboys teammates ended with a 40-40 tie. The Cowboys’ ...

The Arizona Cardinals have a chance at a 3-0 start when they head to San Francisco to take on the 49ers. It's their toughest matchup yet this year.