The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

To this point in the season, the team dealing with the most injuries is arguably the 49ers again, though the Ravens and Bengals have had their seasons thrown off with injuries too. The 49ers and coach Kyle Shanahan did a great job to get to 3-0 given all the players who were out or playing hurt,

Fresh off their first loss of the season, the San Francisco 49ers are playing for first place in the NFC West against the Los Angeles Rams on Thursday. Unfortunately for San Francisco, it will be without one of its most important players for this pivotal divisional tilt.

What’s at stake, injuries, key matchup to watch, TV info, fantasy sleeper and prediction for Thursday night’s game between the NFC West rivals.

San Francisco 49ers offensive lineman Trent Williams is still one of the scariest players in the league, even keeping Jared Verse from trash talking.

Los Angeles Rams wide receiver Davante Adams (17) celebrates his touchdown against the Tennessee Titans during the fourth quarter at Nissan Stadium in Nashville, Tenn., Sunday, Sept. 14, 2025. / Andrew Nelles / The Tennessean / USA TODAY NETWORK via Imagn Images

The Rams' primetime matchup with the 49ers on Thursday night at SoFi Stadium is the NFL's Week 5 highlight. Following a thrilling victory against the Indianapolis Colts in Week 4, the Rams enter the game on a high note.

The Los Angeles Rams beat the San Francisco 49ers in the 2021 NFC championship game thanks in part to one artificial advantage per a former 49er.