The New Orleans Saints (0-3) are considered a massive underdog by 15.5 points as they aim to halt a three-game skid in a matchup against the Buffalo Bills (3-0) on Sunday, September 28, 2025 at Highmark Stadium. The matchup's over/under has been listed at 48 points.

Manzano is taking the Chargers so seriously, he ranked Jim Harbaugh's club at No. 2 overall behind only the defending Super Bowl champion Philadelphia Eagles. The Tampa Bay Buccaneers, San Francisco 49ers and Indianapolis Colts followed No. 3 Buffalo in that order.

New Orleans Saints head coach Kellen Moore speak with the media from the Ochsner Sports Performance Center on Friday, September 26, 2025 ahead of Week 4 vs. the Buffalo Bills.

The football analytics outlet has released their NFL offensive line rankings ahead of Week 4 and the Bills' game against the New Orleans Saints (0-3). Buffalo (3-0) continues to rank well.

The Buffalo Bills are ruling out two key defensive players heading into Week 4 against the New Orleans Saints.

The Buffalo Bills head into Week 4 of NFL action undefeated, now set to face a rather downtrodden team in the New Orleans Saints. The last things the Bills should do is treat an opponent they rare see as an afterthought,

With that, here are five things to watch for during the Bills (3-0) versus Saints (0-3) in Week 4: First, this will be labeled a "trap" game. Buffalo is good, New Orleans... is not. The Saints still should not be overlooked.

Bills rookie Jackson Hawes has a 91.8 PFF grade, the highest of any tight end in the NFL. He’s also the league’s top-graded rookie after three weeks.

The Buffalo Bills were named a suitor for an explosive wideout, but shouldn't be interested in making the move.