Advanced imaging technologies are uncovering surprising roles for CD8+ T cells—not just in immune defense, but also in supporting tissue repair and regeneration.

According to Fernandes, understanding which helper components are necessary for rAAV production could allow for stable cell lines that don’t require helper components.

CD4+ T-cells, primarily considered to play a supportive role in the anti-tumor immune response, have been seen to actively kill cancer cells in a mouse model of melanoma. A recent study by a team at ...

CD4+ T cells can either suppress or promote the antitumor cytotoxic CD8+ T cell responses, either in secondary lymphoid organs or in the tumor. Melanoma treatment depends on the stage of a patient ...

In this study, we found that hypertension leads to proinflammatory Th1 (T helper 1 cell)-like Treg subsets with compromised suppressive capacity. Reconstruction Treg experiments identified that ...

These cells — disease fighters known as "helper T cells" that carry a protein called beta 7 — do not normally have the ability to cross the optic nerve into the eye, but something about the ...

Introduction Human immunodeficiency virus type 1 (HIV-1) differentially infects a variety of cell types, which can be partly explained by differences in CC- or CXC-chemokine receptor expression levels ...

Abstract T cell activation pathways have been repeatedly implicated by genetic studies as being enriched for risk genes for immune and inflammatory diseases. Many of these risk genes code for ...

"Th9 cells are kind of like the black sheep of helper T cells," said senior author Daniella Schwartz, M.D., assistant professor of rheumatology at Pitt's School of Medicine.

CD4+ T cells, or helper T cells, are one type of lymphocyte that helps coordinate the immune response against infection and disease. They interact and activate other cells in the immune system.

T cells belong to the adaptive immune system, which recognizes foreign antigens and specifically fights pathogens. Different T cells perform different functions in this process. So-called T helper ...

The release of the cytokine IL-1α appears to be restricted to a subset of Th17 cells; other T helper cell types do not produce it. "Th17 cells play an important role in fungal infections ...