Santa Colin Cowherd hands out Christmas presents to several NFL teams this holiday season, including the Philadelphia Eagles, ...

The San Francisco 49ers return to Levi's Stadium to host the Detroit Lions on ESPN's Monday Night Football. This matchup ...

Kyle Shanahan ...

Watch the San Francisco 49ers players, staff and their families celebrate the holiday season by supporting over 100 ...

Matos, Jake Tonges and more San Francisco 49ers players talked holiday characters as teammates, shared their favorite festive ...

The Detroit Lions can move one step closer to tying up top spot in the National Football Conference when they travel to the ...

The 49ers' slim postseason hopes came crashing down in Week 16.

Dylan took to social media to remind everyone there is a heartbeat and a pulse. The playoffs, although a long shot, are still ...

The San Francisco 49ers released a statement on the passing of Trent Williams’ son. “The 49ers mourn the passing of Trent Williams' son and send him and his family all our love,” the 49ers ...

Randy Moss, ESPN's Sunday NFL Countdown host and NFL Hall of Fame wide receiver, revealed he is battling with cancer.

San Francisco 49ers head coach Kyle Shanahan reaffirmed his commitment to the organization after a 38-13 win over the Chicago Bears on Sunday. "I don't want to be any place in the world more than ...

Two teams in desperate need of a reset lock horns when the San Francisco 49ers host the Chicago Bears. The Niners find themselves outside the NFC playoff picture during their three-game losing streak.