rarediseaseadvisor

From IPF to Cancer: TGF-β Signaling as a Shared Pathogenic Axis

(Getty Images) In IPF, TGF-β dysregulation may produce a stiff, fibrotic extracellular matrix that supports the development of lung cancer. Idiopathic pulmonary fibrosis (IPF) is a progressive ...
BioWorld

circPTK2 unveiled as a driver of pulmonary fibrosis

Pulmonary fibrosis (PF) is a fatal lung disease characterized by excessive deposition of extracellular matrix proteins in the lung interstitium due to excessive fibroblast activation, which leads to ...
emjreviews.com

Air Pollution and Interstitial Lung Disease: Insights from the Global Burden of Disease Database

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. This work was supported by HCA Healthcare and/or an HCA Healthcare ...
Frontiers

The immune dysregulation of fibrosis: insights into immune-fibrotic crosstalk and potential therapeutic targets

Pulmonary fibrosis is the converging pathological outcome of chronic inflammatory lung diseases with diverse etiologies. Sustained inflammation disrupts immune cell homeostasis, driving aberrant ...
KSDK

Lung cancer's surprising new face: Younger, female, and never smoked a day in their life

ST. LOUIS — When Laura Hamann went in for a scan after a miscarriage, lung cancer was the last thing on anyone's mind. She was in her early 40s. She had never smoked a cigarette in her life. But there ...
CNN

What is a pulmonary embolism, the condition that led to Catherine O’Hara’s death?

A pulmonary embolism was the immediate cause of death for actor and comedian Catherine O’Hara. It’s a serious condition in which a blood clot lodges in the lungs. O’Hara’s sudden passing on January 30 ...
The Cincinnati Enquirer

Movie by Cincy's Markiplier is a box office hit. When will it hit streaming?

A new movie, written and directed by Cincinnati native and YouTube sensation Mark “Markiplier” Fischbach, landed in theaters late last month. Markiplier's directorial debut, "Iron Lung," which ...
The Verge

Iron Lung’s path to theaters was unique, even if the movie isn’t

Posts from this topic will be added to your daily email digest and your homepage feed. The most interesting thing about Markiplier’s horror flick is its journey from YouTube to the big screen. The ...
IGN

Markiplier's Iron Lung Is a Smash Hit at the Box Office — and Already Hugely Profitable

Iron Lung, the low-budget horror film written and directed by YouTuber Markiplier based on the video game of the same name, launched big at the global box office this weekend. It earned $21.5 million ...
New York Post

‘Iron Lung’ smokes its competition on its opener

It breathed life into the box office and smoked the competition. “Iron Lung” was No. 1 in theaters on its opener Friday, taking in $8.9 million, according to The Numbers. The sci-fi horror, based on a ...
IGN

Iron Lung Review

Iron Lung is in theaters now. The mere existence of Iron Lung is impressive. The highly successful, highly viewed YouTuber Mark Fischbach, better known as Markiplier, was so taken with the 2022 game ...