Lineup notes on who's in, who's out and which fantasy football starters are questionable for this weekend's games.

Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

Guerendo (foot, hamstring) has been ruled out for Sunday's game at Miami, Matt Maiocco of NBC Sports Bay Area reports. Guerendo didn't practice this week and thus appears in danger of missing time ...

Guerendo is expected to take over as the 49ers' lead back for the remainder of the regular season after head coach Kyle Shanahan said Monday that both Christian McCaffrey (knee) and Jordan Mason ...

If the San Francisco 49ers want to defend their NFC West title, they must defeat the Los Angeles Rams in Week 15. However, the team enters Thursday Night Footba ...

The San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday at the Miami Dolphins, a source told ESPN's Adam Schefter on Thursday.

Rookie Isaac Guerendo has been elevated to the 49ers’ starting running back after San Francisco had to put both Christian McCaffrey and backup Jordan Mason on the IR on the same day. The news of ...

SANTA CLARA, Calif. -- As the first quarter wound down in his second NFL game, San Francisco 49ers running back Isaac Guerendo trotted on to the field, stepped into the huddle and listened ...

A former track standout and converted wide receiver, Guerendo rushed 14 times for 85 yards and a touchdown and added 17 yards on three receptions as San Francisco took care of Dallas. Isaac ...

SANTA CLARA — When Isaac Guerendo trots onto the field with the first team Sunday at Levi’s Stadium, he will equal the same number of starts he had in five years of college football.

One is on the 53-man roster, and the other is on the practice squad. Guerendo, a fourth-round rookie out of Louisville, is expected to have a chance to operate as San Francisco's lead back with ...